Abstract
Antibiotics and pharmaceutical products cannot remove by conventional sewage treatment. In this work, an effective adsorbent magnetic multiwalled carbon nanotube (Fe3O4@MWCNTs) was synthesized by co-precipitation of MWCNTs with Fe3O4 and used for removal of Metronidazole from aqueous solutions. Response surface methodology on central composition design (CCD) was applied for designing of experiments and building of models for Metronidazole removal before a determination by HPLC. Four factors including pH, the adsorbent dose, time, and temperature were studied and used for the quadratic equation model to the prediction of optimal points. By solvent the equation and considering the regression coefficient (R2 =0.9997), the optimal points obtained as follows: pH =2.98; adsorbent dosage =2.16 g; time =22 min and temperature = 37.9 o C. The isotherm study of adsorption showed that the metronidazole adsorption on Fe3O4@MWCNTs follows the Langmuir model. The maximum adsorption capacity (AC) is 215 mg g-1 obtained from Langmuir isotherm.
Highlights
Antibiotic residual in environmental ecosystems is a serious concern for human’s health
Design of Experiments were conducted using the Response surface methodology (RSM) as well as factors affecting on absorption process of metronidazole such as pH, adsorbent dosage, time, and the temperature were optimized
Experimental design central composition design (CCD) was applied in this work to investigation of variables for adsorption of metronidazole on to MMWCNTs
Summary
Antibiotic residual in environmental ecosystems is a serious concern for human’s health. Many pharmaceutical industries discharge this antibiotic in environmental water by higher dosage [5] Several methods such as fenton process, filtration and adsorption were used for removal of metronidazole from different matrix and determined with HPLC [6]. Combining liquid chromatography with mass spectrometer(LC-MS, HPLC-MS) is the most appropriate method for identifying different species of organic compounds in complex matrixes. Examples of these compound are amino acids, proteins, nucleic acids, hydrocarbons, carbohydrates, drugs, terpenoids and pesticides, antibiotics, steroids, any organic or inorganic metal and a group of various materials. The adsorption Metronidazole based on Fe3O4@MWCNTs was determination by HPLC instrument
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