Abstract
It is known that global drug resistance is increasing challenge at an alarming rate worldwide. Lansoprazole (LPZ) is one of Turkey's most prescribed anti-ulcer drugs to treat acid-related disorders. Turkey is the country with the highest drug resistance among OECD countries. This paper presents a study on LPZ's adsorption evaluation from aquatic media using a modified Iron Oxide (Fe3O4), which was synthesized with Polyethyleneimine (PEI) and Polyoxymethylene Sorbitan Trioleate (Tween 85). The removal efficiency of the PEI@Fe3O4®Tween-85 reached 96 % within 30 min. at pH 8. Even with 0.2 g adsorbent, >90 % LPZ removal was achieved. Significant removal of LPZ was observed after 1 min. Contact time. This process indicates that the LPZ adsorption is physical and demonstrates a thermodynamic behavior of an exothermic reaction. Pseudo-second order kinetics revealed a reasonable regression value (>0.99) that the model is best fitted. The Freundlich isotherm model well described equilibrium adsorption data. The maximum adsorption capacity of Lansoprazole was 131.06 mg/g by the magnetite composite adsorbent. Experimental results demonstrate that this adsorbent possessed the advantages of superior adsorptive to the PEI surface, rapid synthesis, and pore diameters in the range of 70–100 nm (nanoscale) after hydrophobic modification.
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