Remote Ischemic Postconditioning May Provide Limited Protection in Rats with Subarachnoid Hemorrhage

Abstract

Background: Subarachnoid hemorrhage (SAH) is a major form of hemorrhagic stroke. It is not known whether remote ischemic postconditioning (RIP), a promising method to induce neuroprotection, can improve neurological outcome after SAH. Methods: SAH was induced by endovascular perforation of a right cerebral artery in adult Sprague-Dawley male rats. RIP was performed 5 minutes later by three cycles of 10 minutes ischemia and 10 minutes reperfusion to the bilateral legs. Results: SAH reduced neurological scores, induced brain edema and increased blood-brain barrier permeability. RIP did not affect the neurological scores and brain edema but partly inhibited the increase of blood-brain barrier permeability after SAH. Conclusions: These results suggested that RIP may not significantly induce neuroprotection against SAH. Citation: Yun-Zhen Wang, Ru-Quan Han, Zhi-Yi Zuo. Remote ischemic postconditioning may provide limited protection in rats with subarachnoid hemorrhage. J Anesth Perioper Med 2015; 2: 231-5. doi: 10.24015/JAPM.2015.0031This is an open-access article, published by Evidence Based Communications (EBC). This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium or format for any lawful purpose. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.