Remote 1,5-induction and steric approach control in Horner–Wadsworth–Emmons reactions. The stereoselective construction of trisubstituted, exocyclic double bonds from unsymmetric cyclic ketones

Abstract

The stereoselective formation of exocyclic α,β-unsaturated ester 8b from cyclic ketone 4 has been accomplished (E/Z= 9:1).