Abstract
This review compares the functional characteristics of liver mitochondria isolated from (i) the hibernating animals and (ii) of mitochondria studied in situ in motile Tetrahymena pyriformis during stationary growth phase, washed with a substrate-free medium. To explain the considered data, a hypothesis is proposed that the prerequisite for surviving under metabolic depression is a rearrangement of mitochondrial morphology to a condensed state. Such remodeling is induced either (1) by low mitochondrial electrical potential difference across the inner mitochondrial membrane for Tetrahymena, or (2) by low temperature for liver mitochondria. A special methodical part is focused on sources of errors and selection of suitable methods during metabolic depression investigation.
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