Abstract
Intensive chemotherapy was administered to 20 adults with acute leukemia for remission induction. A combination of 6‐mercaptopurine, methotrexate, vincristine, and predni50ne was used in 8 patients. Arabinosyl cytosine and cyclophosphamide in combination with or without vincristine and prednisone was used in 12 patients. Six of 8 patients with acute myelogenous leukemia and 5 of 8 patients with acute nonmyelogenous leukemia who received adequate therapy responded. The response rate for all patients including those who died without the benefit of adequate therapy was 60 per cent. Nonfatal hemorrhage occurred commonly during therapy. Gram‐negative infections were the most common complications causing death in the patients who did not achieve remission. Supportive care in the form of transfusion of platelets, packed red blood cells and prompt effective antibiotic therapy wm essential for the success of antileukemic therapy. These modalities of therapy have resulted in an improvement of the remission rate and survival in patients with acute leukemia at Brooke General Hospital.
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