Remineralization potential of grape seeds extract gel versus casein phosphopeptide-amorphous calcium phosphate in white spot lesions in post orthodontic patients: A randomized clinical trial

Abstract

Aims: To determine the effectiveness of grape seed extract (GSE) gel compared to Casein Phosphopeptide-Amorphous Calcium Phosphate (CPP-ACP) application in managing white spot lesions (WSLs) in post orthodontic patients. Statistical analysis used: All statistical calculations were done using computer program IBM SPSS advanced statistics (Statistical Package for Social Sciences), version 25 (SPSS Inc., Chicago, IL). Methods and Material: This study was a single-blinded randomized clinical trial where 24 participants with white spot lesions in at least two teeth were included and randomized into two groups (12 patients each) to receive either GSE gel or CPP-ACP paste application. GSE gel was used on WSLs after orthodontic treatment every week, while CPP-ACP paste was applied twice daily by the patients themselves. Baseline and post-intervention measurements of quantitative changes of WSLs were measured by KaVo DIAGNOdent at 1, 3 and 6 months. Data for quantitative changes of WSLs were recorded and analyzed for each group. Results: There was no statistically significant difference in overall DIAGNOdent mean readings between GSE gel and CPP-ACP paste groups at P=0.360. Conclusions: Based on the data obtained in this study, it is suggested that GSE promotes remineralization of WSLs post orthodontic treatment and, thus, might be considered an effective natural agent for treatment of early enamel carious lesions.