Abstract
BackgroundThis study investigated the remineralisation effect of bioactive glass on artificial dentine caries.MethodsDentine disks with artificial caries were treated with bioactive glass (group BAG), casein phosphopeptide–amorphous calcium phosphate (CPP-ACP) (group CPP-ACP), sodium fluoride glycerol (group F) or deionized water (group W). All disks were subjected to pH cycling for 28 days subsequently. The topography, microhardness and remineralisation depth of the dentine carious lesion were assessed by atomic force microscopy (AFM), microhardness testing and confocal laser scanning microscope (CLSM), respectively.ResultsAFM images indicated mineral depositions on the surface of the carious lesion in group BAG. The changes of Vickers hardness number (ΔVHN, mean ± SD) after pH cycling were 9.67 ± 3.60, 6.06 ± 3.83, 5.00 ± 2.19 and − 1.90 ± 2.09 (p < 0.001) in group BAG, group CPP-ACP, group F and group W, respectively. The remineralisation depth (mean ± SD) of the carious lesion in group BAG, group CPP-ACP, group F and group W were 165 ± 11 μm, 111 ± 11 μm, 75 ± 6 μm and 0 μm (p < 0.001), respectively.ConclusionBioactive glass possessed a promising remineralisation effect on artificial dentine caries and could be a therapeutic choice for caries management.
Highlights
This study investigated the remineralisation effect of bioactive glass on artificial dentine caries
We observed that dentine collagen fibres were not exposed on the relatively smooth surface of the bioactive glass (BAG), fluoride and casein phosphopeptide– amorphous calcium phosphate (CPP-ACP) treated dentine (Fig. 2 a, 12B and 2C)
Group BAG and Group CPP-ACP presented larger ΔVHN when comparing with Group F (p < 0.001)
Summary
This study investigated the remineralisation effect of bioactive glass on artificial dentine caries. Dental caries (tooth decay) is one of the most prevalent chronic disease [1]. The traditional management of dentine caries has focused primarily on treatment via the excision of diseased tissues and the subsequent restoration of the defect [2]. Retaining demineralised dentine which has no bacteria invasion and restored it with bioactive materials which has remineralization capability is the trend of caries treatment. This procedure can prevent further bacterial infection, and preserve dental hard
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