Abstract
The term cancer has been concomitant with despair, agony, and dreadful death. Like many other diseases, herbal therapy has been used to prevent or suppress cancer. The present study investigated the capability of the decoction of Teucrium polium L. from Lamiaceae family to protect liver cells against hepatocellular carcinoma in carcinogenesis-induced animal model. After 28 weeks of treatment with decoction of Teucrium polium L., serum biochemical markers including ALT, AST, AFP, GGT, ALP, HCY, TNF-α, α2MG, and CBG have been regulated auspiciously. Total antioxidant status also has been increased intensely. Liver lesion score in treated group was lessened and glucocorticoid activity has been intensified significantly. In conclusion, Teucrium polium L. decoction might inhibit or suppress liver cancer development.
Highlights
Hepatocellular carcinoma (HCC), the predominant form of liver cancer, is the sixth most common cancer and the third most frequent cause of cancer-related death worldwide [1, 2]
Patients diagnosed with HCC have a poor prognosis due to the violent nature of the disease [3]
As herbal decoctions are one of the major techniques in herbal medicine and could be drunk as a Evidence-Based Complementary and Alternative Medicine part of daily dietary intake, in the present study, the effect of T. polium decoction has been investigated on hepatocellular carcinoma in animal model
Summary
Hepatocellular carcinoma (HCC), the predominant form of liver cancer, is the sixth most common cancer and the third most frequent cause of cancer-related death worldwide [1, 2]. Complementary medicine has been commonly considered in cancer. Herbal medicine has been widely used to cure or prevent diseases since ages. T. polium has been tested and showed beneficial effects on nonalcoholic steatohepatitis [14] and it has been shown to be considered as an effective and safe chemosensitizer agent for cancer therapy [15]. In vitro study on its aqueous extract has shown that it can effectively inhibit oxidative processes and has substantial antioxidant activity [16]. As herbal decoctions are one of the major techniques in herbal medicine and could be drunk as a Evidence-Based Complementary and Alternative Medicine part of daily dietary intake, in the present study, the effect of T. polium decoction has been investigated on hepatocellular carcinoma in animal model
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