Abstract
BackgroundOur study was aimed to validate a modified RBD (REM sleep behavior disorder) single question (RBD1Q-C), study the prevalence of probable RBD (pRBD) in a rural community based on RBD1Q-C and investigate the association between pRBD and Parkinson’s disease (PD).MethodsThe validation study of RBD1Q-C included 32 Chinese participants (14 idiopathic RBD patients and 18 controls). All participants underwent a polysomnogram (PSG). We then conducted a door-to-door survey to estimate the prevalence of pRBD assessed by RBD1Q-C, and its association with PD among 19614 residents who lived in Malu community of Shanghai, China.ResultsRBD1Q-C demonstrated a high sensitivity of 100 %, a moderate specificity of 55.6 %. The agreement between RBD1Q-C and PSG-based RBD diagnosis was good (k = 0.552). PPV of the RBD1Q-C was 63.6 % and NPV was 100 %. The prevalence of pRBD in Malu community was 4.9 %. In people over 50 years old, presence of pRBD was significantly associated with increased risk of having PD (odds ratio = 2.61, 95 % CI: 1.56–4.39).ConclusionRBD1Q-C was shown to be a useful screening tool. Based on the RBD1Q-C, we found that pRBD was not rare in Chinese rural population and associated with odds of PD, calling for more attention from patients, caregivers and physicians.Electronic supplementary materialThe online version of this article (doi:10.1186/s12883-016-0640-1) contains supplementary material, which is available to authorized users.
Highlights
Our study was aimed to validate a modified RBD (REM sleep behavior disorder) single question (RBD1Q-C), study the prevalence of probable RBD in a rural community based on Chinese REM sleep behavior disorder single question (RBD1Q-C) and investigate the association between pRBD and Parkinson’s disease (PD)
RBD1Q-C consists of a single question, answered “yes” or “no,” as follows “Did you have the following conditions that you shout, yell, move your arms or legs in response to your dream contents, even fallen off your bed?” (Additional file 1)
The prevalence of pRBD diagnosed by RBD1Q-C was 4.9 %, higher in women than men. pRBD was associated with PD in people over 50 years
Summary
Our study was aimed to validate a modified RBD (REM sleep behavior disorder) single question (RBD1Q-C), study the prevalence of probable RBD (pRBD) in a rural community based on RBD1Q-C and investigate the association between pRBD and Parkinson’s disease (PD). Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia characterized by dream enactment behaviors in the setting of increased electromyographic activity during REM sleep [1]. These dream enactment behaviors occur almost always in the setting of an upsetting dream and present as sleep talking, shouting, and vigorous or elaborate body movements including punching, kicking, sitting up, and even falling out of bed [2]. The REM Sleep Behavior Disorder Single-Question Screen (RBD1Q) was developed and validated to be an applicable and short diagnostic screening tool [7]. The RBD1Q can detect RBD with 94 % sensitivity and 87 % specificity in a well-characterized, clinic-based cohort of RBD patients and controls
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