REM sleep behavior and motor findings in Parkinson's disease: A cross sectional analysis

A Mahajan,L Rosenthal,C Gamaldo,R Salas,G Pontone,A Mccoy,C Umeh,Z Mari

doi:10.1016/j.sleep.2015.02.029

Abstract

Background : Parkinson's disease (PD) represents a major public health challenge that will only grow in our aging population. Understanding the connection between PD and associated prodromal conditions, such as rapid eye movement sleep behavioral disorder (RBD), is critical to identifying prevention strategies. However, the relationship between RBD and severity of motor findings in early PD is unknown. This study aims to examine this relationship. Methods : The study population consisted of 418 PD patients who completed the Movement Disorders Society‐United Parkinson's Disease Rating Scale (MDS‐UPDRS) and rapid eye movement sleep (REM) disorder questionnaires at the baseline visit of the Michael J. Fox's Parkinson's Progression Markers Initiative (PPMI). Cross‐sectional analysis was carried out to assess the association between REM Sleep Behavior Screening Questionnaire score and MDS UPDRS‐3 (motor) score categories. Correlation with a higher score category was described as “worse motor findings”. A score of 5 on the REM disorder questionnaire was defined as predictive of RBD. Results : Out of the 418 PD patients, 113 (27.0%) had RBD. With univariate logistic regression analysis, individuals with scores predictive of RBD were 1.66 times more likely to have worse motor findings (p = 0.028). Even with age, gender, and Geriatric Depression Scale scores taken into account, individuals with scores predictive of RBD were 1.69 times more likely to have worse motor findings (p = 0.025). Discussion : PD patients with RBD symptoms had worse motor findings than those unlikely to have RBD. This association provides further evidence for the relationship between RBD and PD.

Highlights

As medical advances extend human life, the prevalence of age-related diseases, including Parkinson’s disease (PD) will increase worldwide.[1]
Of the 418 PD patients included in this analysis, 113 (27%) were classified as PD patients with likely rapid eye movement sleep behavioral disorder (RBD), while 305 (72.9%) were classified as unlikely RBD
Using Question 6 as a tool for identifying patients with likely RBD, the odds of having worse motor findings in PD patients with likely rapid eye movement sleep (REM) sleep behavior disorder are 0.71 times compared to PD patients unlikely to have REM sleep behavior disorder (p50.115, 95% CI: 1.08– 2.22)

Summary

Introduction

As medical advances extend human life, the prevalence of age-related diseases, including Parkinson’s disease (PD) will increase worldwide.[1]. Understanding the connection between PD and associated prodromal conditions, such as rapid eye movement sleep behavioral disorder (RBD), is critical to identifying prevention strategies. Methods: The study population consisted of 418 PD patients who completed the Movement Disorders Society-United Parkinson’s Disease Rating Scale (MDSUPDRS) and rapid eye movement sleep (REM) disorder questionnaires at the baseline visit of the Michael J. With univariate logistic regression analysis, individuals with scores predictive of RBD were 1.66 times more likely to have worse motor findings (p50.028). Gender, and Geriatric Depression Scale scores taken into account, individuals with scores predictive of RBD were 1.69 times more likely to have worse motor findings (p50.025). Discussion: PD patients with RBD symptoms had worse motor findings than those unlikely to have RBD This association provides further evidence for the relationship between RBD and PD

Objectives

Methods

Results