Abstract
20072 Background: RELMb (resistin-like molecule) represents the closest related human homologue of mouse RELMa, also known as hypoxic-induced-mitogenic-factor (HIMF). However, no orthologous gene of mouse HIMF exists in human. Results and Methods: In this study, we cloned human RELMb cDNA from lung and performed regulatory and functional expression studies in adenocarcinoma A549 cell line. RELMb mRNA was found to be strongly upregulated in hypoxia in these cells. Upon transfection of a RELMb encoding expression plasmid, we observed significant induction of proliferation in A549 cells, which could be blocked by phosphatidyl-inositol 3-kinase (PI3K) inhibitors LY294002 and wortmannin. Conclusions: The results suggest that human RELMb may contribute to hypoxic-induced proliferative responses in adenocarcinoma cells via PI3K dependent signal transduction. No significant financial relationships to disclose.
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