Reliability of motor cortex transcranial magnetic stimulation in four muscle representations

Abstract

Objective Motor cortex plasticity may underlie motor recovery after stroke. Numerous studies have used transcranial magnetic stimulation (TMS) to investigate motor system plasticity. However, research on the reliability of TMS measures of motor cortex organization and excitability is limited. We sought to test the reliability of these TMS measurements. Methods Twenty healthy volunteers were tested twice over a two-week period using TMS to determine motor threshold, map topography, and stimulus–response curves for first dorsal interosseous (FDI), abductor pollicis brevis (APB), extensor digitorum communis (EDC), and flexor carpi radialis (FCR) muscles. Results We found moderate to good test–retest reliability TMS measurements of motor threshold (ICC=0.90–0.97), map area (ICC=0.63–0.86) and location (ICC=0.69–0.86), and stimulus–response curves (ICC=0.60–0.83). Conclusions TMS assessments of motor representation size, location, and excitability are generally reliable measures, although their reliability may vary according to the muscle under investigation. Significance These results suggest that TMS measurements of motor cortex function are reliable enough to be potentially useful in investigation of motor system plasticity.