Reliability of mannitol for fluid responsiveness test in patients undergoing intracranial surgery

Abstract

Objective To evaluate the reliability of mannitol for fluid responsiveness test in the patients undergoing intracranial surgery. Methods Sixty-two ASA physical status Ⅰ or Ⅱ patients, aged 18-64 yr, with body mass index of 18-25 kg/m2, scheduled for elective intracranial surgery, were enrolled in the study.The patients were mechanically ventilated after induction of anesthesia.The radial artery and central vein were cannulated, and FloTrac™/Vigileo™ system was connected for stroke volume variation monitoring.Before infusion of mannitol, effective circulating blood volume was confirmed according to stroke volume variation.20% mannitol 250 ml was infused over 20 min starting from onset of craniotomy.The fluid responsiveness test was recorded at the end of mannitol infusion. Results The sensitivity of fluid responsiveness test was 43%, and the specificity of fluid responsiveness test was 44%. Conclusion Mannitol can not be used for fluid responsiveness test in the patients undergoing intracranial surgery. Key words: Mannitol; Diagnostic tests, routine; Fluid therapy; Neurosurgical procedures