Abstract
Introduction: The purpose of our study was to determine the reliability of pituitary abnormalities on magnetic resonance imaging (MRI) as an indicator of hypopituitarism in children with optic nerve hypoplasia. Methods: Retrospective analysis of 41 children with optic nerve hypoplasia evaluated at Arkansas Children's Hospital between 2002 - 2009. All patients had MRI of the brain/sella interpreted by a neuroradiologist masked to the patient's endocrinologic status. All patients had clinical evaluation by a pediatric endocrinologist and a standardized panel of serologic testing that included a complete blood count, electrolytes, cortisol, ACTH, TSH, Free T4, IGF-1, IGF-BP3 levels.
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