Abstract
The Myositis Activity Profile (MAP) is the only disease-specific questionnaire to assess limitations in activities of daily living (ADL) in patients with inflammatory myopathy (IM). Because a German version does not currently exist, this study’s aim was to translate the MAP and assess reliability and construct validity of the new version. Therefore, a cross-cultural adaptation was performed following international guidelines. Forty-eight patients with IM completed the German-MAP, twice within two weeks. They were also assessed using the Health Assessment Questionnaire (HAQ), 36-Item Short Form Survey (SF36), Manual Muscle Test (MMT8), Quantitative Muscle Testing (QMT) and Functional Index (FI-2). For discriminant validity, 48 age-and gender-matched healthy controls completed the German-MAP. Reliability was assessed using weighted kappa (Kw). Correlations between the MAP and the HAQ, the physical (PCM) and mental (MCS) component scores of SF36 and the MMT8 and QMT muscle tests were assessed using Spearman correlation analysis. Discriminative validity was assessed by calculating the Area under the Curve (AUC). The German-MAP showed substantial reliability for the four subscales (Kw: 0.65–0.71) and moderate to substantial reliability for the single items (Kw: 0.57–0.77). The MAP showed good construct validity (high correlations with HAQ and PCM, moderate with FI-2, QMT and MMT8 and poor with MCS and pain) and acceptable discrimination for three subscales and two single items (AUC: 0.65–0.79). In conclusion, the German-MAP appears to be a reliable and valid questionnaire to assess ADL-limitations in patients with IM. Further research is required, both to substantiate these results and to evaluate responsiveness.
Highlights
Inflammatory myopathies (IMs), including polymyositis (PM) and dermatomyositis (DM), are chronic, idiopathic inflammatory muscle diseases characterized by decreased muscle strength and endurance, general fatigue, and, in some cases, muscle pain and extra- muscular manifestations such as lung fibrosis [1]
A healthy control group individually matched by age and gender was recruited
From the 76 patients invited to participate in this study, 28 declined because of “lack of time”, “bad health condition” or “no interest”
Summary
Inflammatory myopathies (IMs), including polymyositis (PM) and dermatomyositis (DM), are chronic, idiopathic inflammatory muscle diseases characterized by decreased muscle strength and endurance, general fatigue, and, in some cases, muscle pain and extra- muscular manifestations such as lung fibrosis [1]. The most prominent clinical features in all subcategories of IMs are proximal and (often) symmetric muscle weakness and low muscle endurance, combined with progressive decline of functional performance over a period of weeks or months. This results in significant difficulties in everyday tasks, such as self-care or household chores, combined with limited community mobility [6, 7]
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