Abstract
age, education, gender, and study visit. They were also matched on baseline Mini-Mental Status Exam (MMSE) and matched visit global Clinical Dementia Rating Scale (CDR). Images were processed as per the ADNI protocol. Results: Independent samples t-tests demonstrated significantly increased activity in the left temporal, left anterior insula and right anterior insular regions. The left temporal volume of interest (VOI) had 21 voxels, centered at Montreal Neurological Institute (MNI) coordinates x 1⁄440 , y1⁄40 , z1⁄4 34. The left insula VOI had 45 voxels centered at MNI coordinates x 1⁄4 30, y1⁄414, z1⁄410. The right insula VOI had 151 voxels centred at MNI coordinates x1⁄4 32, y1⁄426, z1⁄44. Conclusions: These regions (temporal lobe, insular cortices) are involved in sensory and emotional processing and have been previously implicated in neuroimaging studies of delusions in dementia. Future studies should attempt to replicate these findings in a larger sample of patients.
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