Relevant factors of pulmonary arterial smooth muscle cells proliferation and pulmonary arterial hypertension

Abstract

Pulmonary arterial hypertension (PAH) is a disease of unknown etiology that leads to a progressive increase in pulmonary vascular resistance (PVR), if untreated, ultimately right heart failure and high mortality.It is concerted pulmonary vascular contraction and vascular remodeling are the 2 main courses of physiology and pathology leading to PAH, especially the significant role of proliferation of pulmonary arterial smooth muscle cells.A lot of relevant factors are revealed to take a participation into regulating the proliferation of pulmonary arterial smooth muscle cells and finally PAH. Key words: Pulmonary arterial smooth muscle cell; Cell proliferation; Relevant factor; Pulmonary arterial hypertension