Abstract
Breast cancer is a malignant neoplasm originating from breast tissue, most commonly from the inner lining of milk ducts or the lobules that supply the ducts with milk. ILCs and IDCs vary from each other with respect to various histological, biological and clinical features. Remarkably, ductal tumors tending to form glandular structures, whereas lobular tumors are less cohesive and tends to invade in single file. The high degree of similarity in the prognoses of IDC and ILC makes it beneficial to develop a differential diagnostic protocol to classify the two conditions. The main goal of the study is to construct the genetic regulatory network from the microarray data using biological knowledge and constraint-based inferences, in order to explore the potential significant gene regulatory networks that can differentiate IDC and ILC and thereby understand the complex interactions that are influenced by the genetic networks. Out of the 54676 genes present on the GPL570 platform- 29 genes exhibited 4 fold up regulation in case of IDC and 22 in the case of ILC. The ductal and lobular tumors displayed a striking difference in the expression of genes associated with cell adhesion, protein folding, and protein phosphorylation and invasion. Construction of separate gene regulation networks for IDC and ILC on the basis of gene expression altercation can be utilized in understanding the distinction in the possible mechanism that underlies the pathological differences between the two, which can be exploited in identifying diagnostic or therapeutic targets.AbbreviationsILC - Invasive lobular c carcinoma, IDC - invasive ductal carcinoma, ER - Estrogen Receptor.
Highlights
Cancer is an abnormal growth of cells caused by multiple changes in gene expression leading to dysregulated balance of cell proliferation and cell death and evolving into a population of cells that can invade tissues and metastasize to distant sites, causing significant morbidity and, if untreated, death of the host.Breast cancer is a malignant neoplasm originating from breast tissue, most commonly from the inner lining of milk ducts or ISSN 0973-2063 0973-8894Bioinformation 8(8): 359-364 (2012)BIOINFORMATION open access the lobules that supply the ducts with milk [1]
The main goal of the study is to construct the genetic regulatory network from the microarray data using biological knowledge and constraint-based inferences, in order to explore the potential significant gene regulatory networks that can differentiate invasive ductal carcinoma (IDC) and Invasive lobular carcinoma (ILC) and thereby understand the complex interactions that are influenced by the genetic networks
Dataset Collection A comprehensive search of all eligible studies on differential gene expression of IDC and ILC was made by searching the electronic literature (PubMed database) for relevant published reports and by manual searching of reference lists of articles on this topic
Summary
Cancer is an abnormal growth of cells caused by multiple changes in gene expression leading to dysregulated balance of cell proliferation and cell death and evolving into a population of cells that can invade tissues and metastasize to distant sites, causing significant morbidity and, if untreated, death of the host.Breast cancer is a malignant neoplasm originating from breast tissue, most commonly from the inner lining of milk ducts or ISSN 0973-2063 (online) 0973-8894 (print)Bioinformation 8(8): 359-364 (2012)BIOINFORMATION open access the lobules that supply the ducts with milk [1]. Cancer is an abnormal growth of cells caused by multiple changes in gene expression leading to dysregulated balance of cell proliferation and cell death and evolving into a population of cells that can invade tissues and metastasize to distant sites, causing significant morbidity and, if untreated, death of the host. Breast cancer is a malignant neoplasm originating from breast tissue, most commonly from the inner lining of milk ducts or ISSN 0973-2063 (online) 0973-8894 (print). Breast cancer is the second leading cause of cancer deaths in women today (after lung cancer) and is the most common cancer among women, excluding nonmelanoma skin cancers. According to the American Cancer Society, about 1.3 million women will be diagnosed with breast cancer annually worldwide and about 465,000 will die from the disease [2]. Breast MRI, biopsy, ultrasound, CT scan, Mammography, lymph node biopsy are the most common protocols employed in the diagnosis of breast cancer
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