Abstract
BackgroundUntil now, there are few studies evaluating serum levels of angiogenic cytokines in dermatomyositis (DM). Therefore, the aims of the present study were: (a) to analyze systematically and simultaneously serum levels of angiogenin (ANG), angiopoietin (ANGPT)-1, vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF)-1 and − 2, platelet derived growth factor (PDGF)-AA and -BB in DM; (b) to correlate the serum level of these cytokines with the DM clinical and laboratory features.MethodsThis is a cross sectional study, in which 48 patients with DM aged 18 to 45 years were gender-, age- and ethnicity-matched with 48 healthy individuals (control group). The serum levels of cytokines analyses were performed by multiplex immunoassay. The parameters of DM activity were based on the scores established by the International Myositis Assessment & Clinical Studies Group.ResultsThe mean ages, gender frequencies and ethnicities were comparable between the patients with DM and the control group. A significantly higher serum FGF-1 and FGF-2 levels (P < 0.001 and P < 0.001, respectively), lower VEGF and PDGF-AA levels (P = 0.009 and P = 0.022), and comparable ANG, ANGPT-1 and PDGF-BB levels were observed in DM patients compared to controls. There was a tendency for cytokines (with the exceptions of VEGF and PDGF-BB) to correlate positively with the DM activity parameters, whereas FGF-2 correlated inversely. Moreover, FGF-1 strongly correlated with DM cutaneous manifestations.ConclusionsThe present data provide the relevance of different serum angiogenic cytokines in patients with DM. Additional studies will be needed to validate the data obtained in this work.
Highlights
Until now, there are few studies evaluating serum levels of angiogenic cytokines in dermatomyositis (DM)
Several serum angiogenic cytokines have been described in the literature, including: angiogenin (ANG), angiopoietin-1 (ANGPT-1), vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF) types 1
FGF-1 was positively correlated with the cutaneous clinical manifestations and some disease activity parameters, which was in contrast with FGF-2
Summary
There are few studies evaluating serum levels of angiogenic cytokines in dermatomyositis (DM). The aims of the present study were: (a) to analyze systematically and simultaneously serum levels of angiogenin (ANG), angiopoietin (ANGPT)-1, vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF) and − 2, platelet derived growth factor (PDGF)-AA and -BB in DM; (b) to correlate the serum level of these cytokines with the DM clinical and laboratory features. Several serum angiogenic cytokines have been described in the literature, including: angiogenin (ANG), angiopoietin-1 (ANGPT-1), vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF) types 1. High serum VEGF levels have been noted in DM and polymyositis (PM) [9,10,11]. Kadono et al [13] observed an elevated serum FGF-2 level in DM patients that correlated with the serum creatine phosphokinase (CPK) level and pulmonary fibrosis
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