Abstract
The diverse roles of cytokines as IL-6 and IL-8 have been studied in terms of their SNPs in many diseases but their role in prostate cancer (PCa) is still uncertain. Aim. To determine the relevance of IL-6 rs1800795 SNP and/or IL-8 rs2227306 SNP with prostate cancer's risk. Subjects and Methods. 40 PCa patients, 40 benign prostate hyperplasia (BPH) patients, and 40-age-matched-control group were enrolled in the study. Genotyping of IL-6 rs1800795 (G/C) SNP and IL-8 rs2227306 (C/T) SNP was determined using real-time PCR. Results. High frequency of IL-6 rs1800795GG and IL-8 rs2227306CC genotypes was noticed among PCa patients with associated OR 10.091 and 8.143, respectively. Comparisons based on allele frequencies revealed that IL-6G and IL-8C alleles are more frequent among PCa patients than other groups. Presence of IL-6 rs1800795G and IL-8 rs2227306C alleles in the same patient increase PCa risk by 16.7 times. Statistical correlations between PSA ratio and both of IL-6 and IL-8 SNP did not show any significant relation among PCa patients. Conclusion. IL-6 rs1800795G and IL-8 rs2227306C alleles could be considered risk factors for PCa development, particularly if presented together. However, no relation was found between both cytokines SNP and severity of prostate cancer.
Highlights
Benign prostate hyperplasia (BPH) and prostate cancer (PCa) are chronic, age-related, heterogeneous disorders with a wide variety of clinical presentations and high prevalence among men [1,2,3,4]
Comparisons based on allele frequencies revealed that IL-6G and IL-8C alleles are more frequent among PCa patients than other groups
Several studies have been conducted to investigate the molecular mechanism underlying PCa pathogenesis; some reported that there are specific genes that contribute to PCa risk [2]; others have implicated inflammation as a driver of PCa development [6]; and others stated that genetic mutation and single nucleotide polymorphism (SNP) have a significant role in the progression and severity of PCa but their results were dissimilar in the different populations [2, 8,9,10,11]
Summary
Benign prostate hyperplasia (BPH) and prostate cancer (PCa) are chronic, age-related, heterogeneous disorders with a wide variety of clinical presentations and high prevalence among men [1,2,3,4]. Several studies have been conducted to investigate the molecular mechanism underlying PCa pathogenesis; some reported that there are specific genes that contribute to PCa risk [2]; others have implicated inflammation as a driver of PCa development [6]; and others stated that genetic mutation and single nucleotide polymorphism (SNP) have a significant role in the progression and severity of PCa but their results were dissimilar in the different populations [2, 8,9,10,11]. IL-8 is known to have a role in immune surveillance, recruitment, and degranulation of neutrophils, Prostate Cancer inflammation, and angiogenesis [13]. It is overexpressed in many types of cancer as it has tumorigenic, and proangiogenic properties [5]. Us, the current study aimed to determine the possible association of IL-6 rs1800795 SNP, and/or IL-8 rs2227306 SNP with prostate cancer’s risk and/or severity
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