Relevance of IgE to novel kiwi seed allergens evaluated in kiwi allergic children

Hillevi Englund,Otti Bengtsson‐Gref,Peter Brostedt,Caroline Nilsson,Johanna Hidman

doi:10.1186/2045-7022-5-s3-o24

Abstract

Background Kiwi fruit is a common food allergen and severe allergic reactions are observed. The current diagnostic accuracy is poor with a reported diagnostic sensitivity of 65% in a large European cohort. Recently, two new kiwi allergens were registered, both being storage proteins and both isolated from kiwi seeds. Storage proteins are often linked to severe clinical reactions in other food allergies. The aim of this study was to evaluate sera from Swedish children with documented kiwi allergy, and investigate their IgE-reactivity to purified seed allergens.

Highlights

Kiwi fruit is a common food allergen and severe allergic reactions are observed
Relevance of IgE to novel kiwi seed allergens evaluated in kiwi allergic children Hillevi Englund1*, Johanna Hidman1, Otti Bengtsson-Gref1, Caroline Nilsson2, Peter Brostedt1
Of IgE towards storage proteins in for example nuts, analyses of IgE-reactivity towards 11S, 7S and 2S from kiwi seeds have the potential to lead to new insights in kiwi allergy and possibly improve the diagnostic accuracy of kiwi allergy tests

Summary

Introduction

Kiwi fruit is a common food allergen and severe allergic reactions are observed. The current diagnostic accuracy is poor with a reported diagnostic sensitivity of 65% in a large European cohort. Two new kiwi allergens were registered, both being storage proteins and both isolated from kiwi seeds. Storage proteins are often linked to severe clinical reactions in other food allergies. The aim of this study was to evaluate sera from Swedish children with documented kiwi allergy, and investigate their IgE-reactivity to purified seed allergens. Of IgE towards storage proteins in for example nuts, analyses of IgE-reactivity towards 11S, 7S and 2S from kiwi seeds have the potential to lead to new insights in kiwi allergy and possibly improve the diagnostic accuracy of kiwi allergy tests. Authors’ details 1R&D, ImmunoDiagnostic, Thermo Fisher Scientific, Uppsala, Sweden.

Objectives

Methods

Conclusion