Abstract
The adult articular cartilage has poor intrinsic healing capacity due to its avascular, aneural, and lymphatic nature. As such, the repair of cartilage defects in patient’s knees presents a great challenge to the orthopedic surgeon. If left untreated, cartilage defects can lead to osteoarthritis (OA) resulting in chronic pain and disability. In recent years, the use of tissue engineering (TE) strategies and advances in biochemical and biomechanical properties of cartilage scaffolds have led to the development of a more functional cartilage repair tissue. This chapter will highlight the characteristic features of a successful cartilage scaffold and review the scaffolds that are currently being investigated for clinical used.
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