Abstract
SummaryExperiments were performed for the purpose of grossly identifying the substance responsible for the release, by rat intestinal segment extracts and human organ extracts, of vitamin B12 bound to rat stomach extract or normal human gastric juice. It has been found that the active principle in the proximal area and mid-ileum of the rat small intestine is dialyzable and that its distribution parallels closely that of endogenous vitamin B12. Non-radioactive vitamin B12 has been found to be very active in the release of radioactive vitamin B12 bound to rat or human intrinsic factor concentrate. This appears to be due to its ability to equilibrate with the bound form. In a complex equilibrium system, endogenous vitamin B12 appears to account for substantially all of the activity displayed by the proximal area and mid-ileum of the rat small intestine, and by mucosa homogenates from beef small intestine and various human organ extracts. Vitamin B12 bound to hog intrinsic factor on the other hand shows littl...
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Schedule a callMore From: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
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