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Abstract
1. The in vitro effects of 6-hydroxydopamine (6-OHDA) and 5-hydroxydopamine (5-OHDA) on 3H-efflux from rabbit pulmonary artery after incubation with [ 3H]noradrenaline ([ 3H]NA) or [ 3H]adenosine were assessed. 2. 6-OHDA (100 μM) or 5-OHDA (100 μM) enhanced not only [ 3H]noradrenaline efflux, but also [ 3H]purines efflux. 3. Following Ca 2+-removal, [ 3H]NA and [ 3H]purine effluxes evoked by these hydroxydopamines were moderately and considerably diminished, respectively. In addition, the 6-OHDA-evoked [ 3H]purine efflux was significantly decreased by W-7 (30 μM), a calmodulin inhibitor. 4. The 6-OHDA or 5-OHDA-evoked purine release was almost insensitive for prazosin (0.3 μM), indicating a neuronal release. 5. The peak [ 3H]purine efflux evoked by 6-OHDA or 5-OHDA occurred in the corresponding fraction number to that for the [ 3H]NA efflux. 6. These results suggest that 6-OHDA and 5-OHDA may expel NA together with purines from the amine stored sites (probably, in axoplasm) in the adrenergic nerves.
Published Version
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