Abstract
Slices of mammalian brain accumulate tritiated norepinephrine or serotonin when incubated in a medium with these compounds. Mild electrical stimulation of short duration induces a striking increase in the release of exogenous-labeled amine. Electrically stimulated release of norepinephrine- 3H, but not of serotonin- 3H, is calcium dependent. Stimulation-induced release of both monoamines is significantly diminished by the addition of ouabain, lithium or tetrodotoxin to the perfusing medium. Elevated calcium concentration prevents lithium-induced inhibition of norepinephrine- 3H release but has no effect on lithium inhibition of evoked release of serotonin- 3H. Enhanced calcium levels did not reverse ouabain-induced inhibition of release of either monoamine.
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