Abstract
Abstract The capacity of viruses, as macromolecules, to initiate a specific immune response by the host and the ability of this response to influence the viral infection are well recognized. Less understood are the relative roles played by humoral antibody and cell-mediated, delayed-type hypersensitivity in this process. In passive transfer experiments humoral antibodies have been shown to initiate or intensify the injury of viral infections in animals (1, 2). The influence of cellular immunity upon viral infections has not been satisfactorily explored in vivo but its importance has been suggested by the enhanced susceptibility of individuals with defective cellular immunity to both natural viral infections and vaccinations (3). Recently, the macrophage migration inhibition test has been used as a measure of cellular immunity to a variety of antigens ranging from soluble proteins to bacterial and tumor antigens in several species, including man, guinea pig and mouse (4–7).
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