Abstract
AbstractThe in vitro release of indomethacin from different suppository bases was inverstigated using the USP rotating basket dissolution method. Suppositories containing 100 mg of indomethacin were prepared by the fusion method using theobroma oil, Witepsol, polyethylene glycols, and glycerinated gelatic. The percent released was found to be in the order PEG 3 = PEG 4 - PEG 5 = glycerinated gelatin > theobroma oil = Witepsol. The addition of polysorbate 80 resulted in a significant increase in the percent indomethacin released in the case of fatty bases and a small increase in the case of water-soluble bases.
Full Text 
Sign-in/Register to access full text options
Sign-in/Register to access full text options 
Paper version not known
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
