Abstract
Leukopenia and anaphylatoxin formation occur during cardiopulmonary bypass1,2. Both C3a and C5a are converted to their respective desArg forms by plasma carboxypeptidase, but C5a-desArg still retains its capacity to activate leukocytes2-6. After C5 cleavage C5b-9 complexes are generated on target membranes or SC5b-9 complexes in the fluid phase. Recent studies demonstrated deposition of C5b-9 on blood cells during cardiopulmonary bypass. It was suggested that C5b-9 complexes may be partly responsible for the hemolysis and may augment granulocyte activation by the stimulation of arachidonate metabolism in those cells7.KeywordsCardiopulmonary BypassGranulocyte ElastaseElastase ReleaseLactoferrin LevelGranulocyte ActivationThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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