Abstract
Microencapsulation of salicylic acid using methacrylate copolymers was devised utilizing coacervation by non-solvent addition. Release of salicylic acid as a model of an acid drug from such microcapsules was studied. It was found that the release from individual microcapsules and tablets showed matrix-controlled mechanism. The cationic methacrylate copolymer was different because it reacts with the acidic drugs; the complex formed can form a coacervate which microencapsulates excess drug. Methacrylate copolymers can microencapsulate efficiently the drug in the ratio of 95:5 drug-to-polymer.
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