Abstract
Various type of pendant chain polymeric prodrugs of pindolol were synthesized and their release characteristics were evaluated. Non linear regression analysis of various mathematical models indicated a best fit was obtained in all cases by a concomitant zero and first order release pattern. The effect of load (w/w pindolol) and backbone (polymer type) were studied. An increase on load in the high molecular weight dextran (T - 70) resulted in a proportional increase in fraction of release exhibiting first order kinetics and a proportional decrease in the zero order rate constant. Across the three polymers studied, a polymer with a large first order fraction also had a large zero order rate constant and a faster overall release pattern.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
