Abstract
Hydrophilic 2-hydroxyethyl methacrylate (HEMA) and hydrophobic styrene (St) were introduced into a thermo-responsive gel of acryloyl- l-proline methyl ester (A-ProOMe) by means of radiation-induced copolymerization in the presence of a slight amount of crosslinker. The copolymer gels showed a reversible volume phase transition around 14°C and, as a result, it was found that the introduction of HEMA and St leads to the formation of a ‘matrix pumping’ gel which is characterized by a rapid shrinkage of the whole matrix without the disappearance of pores in the initial stageof deswelling. Such a thermo-responsive function appeared in limited composition ranges; 0–90 mol% HEMA and 0–50 mol% St. 9-β- d-Arabinofuranosyladenine (Ara-A) was incorporated into the A-ProOMe-containing gel to evaluate the release behavior of Ara-A when cycled between 10 and 37°C. The drug resulted in a pulsatile release consisting of a slight amount of drug release at 10°C and a good deal of drug release at 37°C, in closely relation to a matrix pumping mechanism.
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