Release characteristics of four model drugs from drug-loaded electrospun cellulose acetate fiber mats

Abstract

Ultra-fine fiber mats of cellulose acetate (CA; Mw≈30 000Da; degree of acetyl substitution≈2.4) containing four different types of model drugs, i.e., naproxen (NAP), indomethacin (IND), ibuprofen (IBU), and sulindac (SUL), were successfully prepared by electrospinning from 16% w/v CA solutions in 2:1 v/v acetone/N,N-dimethylacetamide (DMAc). The amount of the drugs in the solutions was fixed at 20wt.% based on the weight of CA powder. The morphology of the drug-loaded electrospun (e-spun) CA fiber mats was smooth, with the average diameters of these fibers ranging between 263 and 297nm. No presence of the drug aggregates of any kind was observed on the surfaces of these fibers, suggesting that the drugs were encapsulated well within the fibers. After submersion in the acetate buffer solution at 37°C for 24h, the drug-loaded e-spun CA fiber mats swelled particularly well (i.e., 570–630%), while the corresponding solvent-cast film counterparts did not. The release characteristics of the model drugs from both the drug-loaded CA fiber mats and the drug-loaded as-cast CA films were carried out by the total immersion method in the acetate buffer solution at 37°C. At any given immersion time point, the release of the drugs from the drug-loaded e-spun CA fiber mats was greater than that from the corresponding as-cast films. The maximum release of the drugs from both the drug-loaded fiber mats and films could be ranked as follows: NAP>IBU>IND>SUL.