Abstract
UDP-Glucuronyltransferase activity in chick-embryo liver and kidney, known to be induced by hatching or by culture, appears to be repressed in ovo. Injection of phenobarbital into the egg overcomes this repression. Chick-embryo liver and kidney cells can thus exhibit high transferase levels whilst still in ovo. Response to phenobarbital by liver tissue occurs in situ or when grafted on to the chorioallantoic membrane, and can be elicited by 96 hr of age. The ability of phenobarbital to over-ride the natural regulation of liver UDP-glucuronyltransferase development in ovo is contrasted with its inability in utero. Overall glucuronidation, as well as the transferase, is elicited by phenobarbital in ovo; differences between regulation of glucuronidating and hydroxylating enzymes are noted.
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