Abstract
In this study, we manufactured a polymer blend, using hydroxypropyl methylcellulose (HPMC) and polyvinylpyrrolidone (PVP), by spray drying method to improve the characteristics of polymers. This polymer blend was used to improve the drug delivery of cilostazol, a phosphodiesterase inhibitor that decreases serum triglycerides, is a direct arterial vasodilator, and inhibits platelet aggregation and smooth muscle cell proliferation. Compatibility with this drug was achieved when the polymer blend of HPMC and PVP were spray dried. Various ratios of the two ingredients were blended to determine optimum release rate of this poorly soluble drug. Cilostazol blended with different ratios of HPMC and PVP was analyzed by scanning electron microscopy (SEM) and transmission electron microscopy (TEM) to confirm surface morphology and combination of drug and polymer. Differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FTIR) were conducted to confirm thermodynamic properties and chemical structure change, respectively. Change in the drug release of cilostazol was expected by adjusting the HPMC and PVP blend ratio in gastric juice (pH 1.2). Open image in new window
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
