Abstract
Aloe vera is a perennial plant employed for medical, pharmaceutical and cosmetic purposes that is rich in amino acids, enzymes, vitamins and polysaccharides, which are responsible for its therapeutic properties. Incorporating these properties into a biopolymer film obtained from alginate and chitosan allowed the development of a novel wound dressing with antibacterial capacity and healing effects to integrate the antibacterial capacity of silver nanoparticles with the healing and emollient properties of Aloe vera gel. Three alginate-chitosan matrices were obtained through blending methods using different proportions of alginate, chitosan, the Aloe vera (AV) gel and silver nanoparticles (AgNps), which were incorporated into the polymeric system through immersion methods. Physical, chemical and antibacterial characteristics were evaluated in each matrix. Interaction between alginate and chitosan was identified using the Fourier transform infrared spectroscopy technique (FTIR), porosity was studied using scanning electron microscopy (SEM), swelling degree was calculated by difference in weight, Aloe vera gel release capacity was estimated by applying a drug model (Peppas) and finally antibacterial capacity was evaluated against S. Aureus and P. aeruginosa. Results show that alginate-chitosan (A (1:3 Chit 1/Alg 1); B (1:3 Chit 1.5/Alg 1) and C (3:1 Chit 1/Alg 1/B12)) matrices with Aloe vera (AV) gel and silver nanoparticles (AgNps) described here displayed antibacterial properties and absorption and Aloe vera release capacity making it a potential wound dressing for minor injuries.
Highlights
Traditional treatment for wound healing has been based on gauze or fabric wound dressing
Escherichaalginate and silver inaureus orderfor todiabetic obtain burn an active wound dressing with antimicrobial activity and coli nanoparticles, and Staphylococcus applications we propose to and develop a synergistic association with Aloe vera, chitosan, alginate controlled delivery of both and silver nanoparticles, in order to obtain an active wound dressing with antimicrobial activity and controlled delivery of both Aloe vera and AgNps
The alginate-chitosan matrices loaded with AgNps and Aloe vera gel, which were obtained with the technique proposed in this research, showed great capacity for absorbing Aloe vera gel, due to a porous structure with interconnected pores which facilitates the release of the gel
Summary
Traditional treatment for wound healing (dermatological injuries) has been based on gauze or fabric wound dressing. These kinds of procedures have not been a good option because they do not provide optimum humidity conditions, pH and gas exchange to wounds [1]. On the contrary, these conditions could be an optimum medium for bacteria growth, promoting an infection and making the wound healing process slower [2]. To reduce the risk of infection, numerous products with antimicrobial drugs have been developed, such as silver sulfadiazine, nitrofurazone, and others. Active products obtained from medicinal plants have been emerging as
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