Abstract
The uptake and K +-evoked release of [; 3H];γ-aminobutyric acid (GABA) was examined in tissue slices from rat gastric antrum. Active [; 3H];GABA accumulation was observed that could only be partially inhibited by _diaminobutyric acid (L-DABA), a blocker of neuronal GABA uptake. The L-DABA-insensitive uptake component was saturable, sodium-dependent and of high affinity. Moreover, [ 3H]GABA could be released from this L-DABA-resistant pool by a high K + concentration. It is concluded that a releasable, non-neuronal GABA pool, which may have some functional significance, is present in the gastric antrum.
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