Abstract
THE positive inotropic effect of catecholamines in cardiac muscle is assumed to result from an increase in the intracellular level of cyclic AMP (adenosine 3′,5′-monophosphate)1,2. Cyclic AMP may enhance the contraction by increasing the trans-sarcolemmal flux of Ca2+ during the plateau of the action potential3,4, but the flux seems insufficient to activate directly the myofilaments and it is generally assumed that additional Ca2+ may be released from intracellular stores (ref. 5), possibly by a Ca2+-triggered release from the sarcoplasmic reticulum (SR)6–8.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
