Abstract
Porcine relaxin (30 μg/ml) when incubated with separated myometrial tissue from 20 day pregnant rats inhibited basal prostacyclin output by 50%. However, relaxin did not inhibit the increased prostacyclin output observed when myometrial tissue was incubated with the prostaglandin precursor, arachidonic acid (10 μg/ml). When prostacyclin release was stimulated by incubation with oxytocin (10 mU/ml), however, relaxin completely inhibited the increased output. The results suggest that relaxin interferes with basal and oxytocin-stimulated prostacyclin formation in pregnant myometrial tissue by inhibiting the action of the enzyme phospholipase A 2 which is responsible for liberating the precursor arachidonic acid endogenously.
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