Abstract
Although the genetic code is defined by a linear array of nucleotides, it is the threedimensional structure of the double helix that regulates most of its cellular functions. Over the past two decades, it has become clear that DNA topology influences every facet of nucleic acid physiology. In vivo, DNA topology is modulated by enzymes known as DNA topoisomerases (topos). Type I enzymes (topo I) act by making a transient singlestranded nick, passing another strand through the nick, and changing the linking number by one unit [1]. Topo I have been identified as the primary cellular target for widely used antitumor drugs [2].
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