Abstract
Aims: Asthma is a chronic obstructive pulmonary disease which is a world health problem that is not only infected in developed countries but also in developing countries. According to the National Asthma Education and Prevention Program (NAEPP), asthma can be defined as a chronic inflammatory disorder that occurs in the airways, which involves inflammatory cells. curcumin reduces allergic airway inflammation in mice through inhibition of a specific pathway aimed at investigating the anti-inflammatory effect of curcumin in acute allergic asthma and its underlying mechanisms in mice.
 Study Design: This study is experimental study.
 Methodology: The experimental animals were divided into 2 groups, each group consisting of 4 animals. Group 1 gave theophline as a positive control group and group 2 was given extracts with concentrations (1 mg / ml, 2 mg / ml, 3 mg / ml, 4 mg / ml, 5 mg / ml, 6 mg / ml, 7 mg / ml and 8 mg / ml). These animals are acclimatized for 1 (one) week with the aim of homogenizing their food and life with the same conditions so that they are considered eligible for research.
 Results: The ethanol extract of curcuma longa has no different ability from atropine sulfate 1 x 10-6 M in reducing the smooth muscle contraction of isolated guinea pig tracheal induced by acetylcholine, the strength of acetylcholine without incubation contraction compared to acetylcholine with EETH incubation showed statistically different results (p<0.05).
 Conclusion: The mechanism of the relaxing effect of curcuma longa on isolated mouse smooth muscle is mediated through inhibition of the PDE enzyme.
Highlights
Asthma is a chronic obstructive pulmonary disease a public health problem worldwide contracted in developed countries and in developing countries
According to the National Asthma Education and Prevention Program (NAEPP), asthma can be defined as a chronic inflammatory disorder that occurs in the respiratory tract, which involve inflammatory cells [1,2,3]
According to data from a 2012 Global Initiative for Asthma (GINA) report, it is stated that the estimated number of people with asthma worldwide is three hundred million people, with the number of deaths that continues to increase to 180,000 people per year [6,7,8]
Summary
Asthma is a chronic obstructive pulmonary disease a public health problem worldwide contracted in developed countries and in developing countries. Respiratory tract inflammation found in asthma patients is believed to be the underlying disorder that is the function of airway obstruction that restricts air flow [4,5]. The treatment of asthma consists of two categories: drugs that work as inhibitors of smooth muscle contraction airways (bronchodilators) and -obat drugs that prevent and reduce inflammation. Bronchodilator drugs such as adrenergic agonists, xanthine derivatives and anticholinergics; whereas drugs that prevent and reduce inflammation are glucocorticoids, leukotriene inhibitors and mast cell-stabilizing agent (McFadden, 2001). Of the many varieties of plants in Indonesia that can be developed into traditional medicine, one of them is the turmeric plant (Curcuma longa Linn.) [1416]. Curcumin may be a potential candidate for prevention and / or treatment of several diseases because of its antioxidant, anti-inflammatory activity and excellent safety profile (Noorafshan and Esfahani, 2013)
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