Abstract
The clamped membrane potential of small crayfish muscle fibers was shifted in rapid steps between potentials of about −60 and −120 mV, and the clamp currents measured after de-and hyperpolarizing steps were averaged. In addition, the inhibitory nerver fiber was stimulated either synchronously or asynchronously with the averaging. Synchronous stimulation yielded the usual IPSCs, and asynchronous stimulation a steady state inhibitory current which relaxed to a new level after a voltage step. Fast relaxations were observed in all fibers. Their time constants τ=15 to 20 ms at −60 mV (10°C) decreased on hyperpolarization and agreed with those of the decay of the IPSC at the respective potential. The relaxations could be described quantitatively by a model in which the synaptic current depends on membrane potential due to (1) the potential dependence of the life time τ of a synaptic channel, (2) to a constant channel permeability, and (3) to the potential difference from the equilibrium potentialECl.
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