Abstract
relax: the analysis of biomolecular kinetics and thermodynamics using NMR relaxation dispersion data.
Highlights
Many important biological processes occur on the μs to ms timescale and, for atoms exchanging between different states, Nuclear Magnetic Resonance (NMR) relaxation dispersion can be observed
Using experimental data the solution to these equations reveals both populations of the molecular states and rates of exchange between them
Two NMR dispersion methods are used for analysing motions: single, zero, double, or multiple quantum (SQ, ZQ, DQ, MQ) CPMG (Carr and Purcell, 1954; Meiboom and Gill, 1958); or R1ρ (Deverell et al, 1970)
Summary
Many important biological processes occur on the μs to ms timescale and, for atoms exchanging between different states, NMR relaxation dispersion can be observed. Using experimental data the solution to these equations reveals both populations of the molecular states (thermodynamics) and rates of exchange between them (kinetics). Two NMR dispersion methods are used for analysing motions: single, zero, double, or multiple quantum (SQ, ZQ, DQ, MQ) CPMG (Carr and Purcell, 1954; Meiboom and Gill, 1958); or R1ρ (Deverell et al, 1970).
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