Relavance of peritoneal drainage fluid lactate level in patients with intra-abdominal hypertension

Natasa Kovac,Mladen Siranovic,Mladen Peric,Sunny Hei Wong

doi:10.1080/2331205x.2017.1308083

Natasa Kovac, Mladen Siranovic + Show 2 more

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https://doi.org/10.1080/2331205x.2017.1308083

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Abstract

Objective: The aim of this study was to assess the effect of intra-abdominal hypertension (IAH) on peritoneal fluid lactate, local and systemic organ dysfunctions in patients after major abdominal ...

Highlights

Intra-abdominal hypertension (IAH) frequently develops in patients with an acute abdomen syndrome caused by ileus, intestinal perforation, ruptured abdominal aneurysm, peritonitis, acute pancreatitis and some other non-traumatic as well as trauma-caused conditions (Malbrain et al, 2006; McNelis et al, 2002; Muckart, Ivatury, Leppaniemi, & Smith, 2006)
According to the measured intra-abdominal pressure (IAP) values patients were sorted into the normal intra-abdominal pressure (NIAP) group and the high intra-abdominal pressure (HIAP)
We found statistically significant differences between the HIAP and NIAP groups with respect of daily diuresis, abdominal perfusion pressure (APP), filtration gradient (FG), creatinine clearance, and lactate in peritoneal drainage fluid, but not in prothrombin time, bilirubin and transaminase values

Summary

Introduction

Intra-abdominal hypertension (IAH) frequently develops in patients with an acute abdomen syndrome caused by ileus, intestinal perforation, ruptured abdominal aneurysm, peritonitis, acute pancreatitis and some other non-traumatic as well as trauma-caused conditions (Malbrain et al, 2006; McNelis et al, 2002; Muckart, Ivatury, Leppaniemi, & Smith, 2006). Clinical correlation studies indicated that intra-abdominal pressure (IAP) above 12 mm Hg compromises the regional blood flow and reduces splanchnic tissue perfusion, producing tissue hypoxia, intestinal swelling and dysfunction of other organs (Ivatury & Diebel, 2006; Kovač, Širanović, & Mazul-Sunko, 2007; Raeburn & Moore, 2006; Surgue, Hallal, & D’Amours, 2006). IAP is often increased and abdominal surgery, bacterial translocation, sepsis, endotoxemia, organ failure, mechanical ventilation are associated with an increase in intra-abdominal pressure (Benninger et al, 2012; Raeburn & Moore, 2006; Surgue et al, 2006). Increased IAP can reach values that cause organ dysfunction, and these values vary from patient to patient, and that variability is due to individual reactivity and comorbidity

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