Relative Stability and Diatropic Character of Carbaporphyrin, Dicarbaporphyrin, Tricarbaporphyrin, and Quatyrin Tautomers

Abstract

Monocarbaporphyrins, dicarbaporphyrins, tricarbaporphyrins, and quatyrins can all potentially exist in a number of tautomeric forms, but little is known about these species. In addition, no examples of tricarbaporphyrins or quatyrins are known at this time. In order to get information on the relative stabilities of carbaporphyrin tautomers, a series of aromatic and nonaromatic structures were assessed using computational methods. The conformations of 41 carbaporphyrin structures, together with four tautomers of porphyrin and the related antiaromatic species didehydroquatyrin, were minimized using DFT-B3LYP/6-311++G(d,p). The relative stabilities of the tautomers for each series were computed, and the bond lengths and bond angles were calculated. Many aromatic carbaporphyrin structures have very crowded cavities with up to six hydrogens being present. However, this was not sufficient to destabilize the aromatic structures relative to the nonaromatic forms. Furthermore, nucleus-independent chemical shifts (NICS) demonstrated that all of the porphyrinoids with 18-π-electron delocalization pathways are highly diatropic. adj-Dicarbaporphyrin and tricarbaporphyrin favor tautomers with an internal methylene group, while two interior methylenes are present in the favored tautomers for quatyrin. The results provide valuable information that will be helpful in designing synthetic routes to higher carbaporphyrinoid systems.