Abstract
Results We observed a significant decrease in the total DCs and pDCs population in HIV-1 infected patients (%DCs p = 0.0132, %pDCs p = 0.0281) and IDUs (%DCs p = 0.006, %pDCs (p>0.0001) as compared to healthy individuals. The plasma levels of IFN-g was significantly lower while level of IL-10 was significantly higher in HIV-1 infected patients as compared to IDUs (p = 0.0062, for IFNg and p = 0.0071 for IL-10) and healthy subjects (p = 0.004 for IFNg and p = 0.0068 for IL-10).
Highlights
Dendritic cells (DCs) are professional antigen presenting cells and play a central role in both innate and adaptive immunity
A decrease in one or both subsets of DC has been reported in HIV-1 infected patients from different populations
We observed a significant decrease in the total DCs and pDCs population in HIV-1 infected patients (%DCs p = 0.0132, %pDCs p = 0.0281) and Injecting Drug Users (IDUs) (%DCs p = 0.006, %pDCs (p>0.0001) as compared to healthy individuals
Summary
Dendritic cells (DCs) are professional antigen presenting cells and play a central role in both innate and adaptive immunity. The status of DC subsets in subjects at high risk for HIV-1 such as Injecting Drug Users (IDUs) has not been reported so far
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