Abstract
One hundred sixty-one individuals from each of five US population groups, Caucasians (CAU), African Americans (AFA), Asians/Pacific Islanders (API), Hispanics (HIS), and Native Americans (NAT), were randomly selected from a volunteer bone marrow registry database consisting of 14,452 HLA-DRB1∗11 positive individuals. This sampling provided at least an 80% probability of detecting a rare allele that occurred at 1% in the DRB1∗11 positive population. Samples were typed for DRB1∗11 alleles by polymerase chain reaction-sequence specific oligonucleotide probe typing (PCR-SSOP). A total of 10 DRB1∗11 alleles out of 27 possible alleles were detected. The distribution and diversity of DRB1∗11 alleles varied among populations although DRB1∗1101 was the predominant DRB1∗11 allele in all populations. Caucasians were the least diversified; only four common alleles (DRB1∗1101-∗1104) were observed. As well as the four common alleles, other groups also carried one or two other less frequent alleles including DRB1∗1105 (API), ∗1106 (API), ∗1110 (AFA), ∗1114 (HIS), ∗1115 (NAT), and ∗1117 (AFA). A subset (418) of these individuals were also typed for DRB3 alleles. Most (97.6%) showed a strong association of DRB1∗11 with DRB3∗0202.
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