Abstract
Background and Objectives Recurrent aphthous stomatitis is an inflammatory condition present since ancient era wherein numerous treatment modalities have been tried. But complete eradication of the disease has not been possible and hence newer agents are being introduced. One such agent is a flavonoid named quercetin with proven antioxidant, anti-inflammatory, and ulcer healing properties. Methods 40 patients with minor aphthous ulcers were divided equally into two groups: A and B. Group A patients were advised to apply quercetin gel and Group B patients were advised to take benzydamine hydrochloride mouth wash. Clinical evaluation including assessment of ulcer size and pain score and questionnaire about the acceptability of both the drugs in terms of taste and ease of application was carried out. Each criterion was compared and statistically analyzed. Results There was statistically significant reduction in the mean score of pain sensation and ulcer area in both the groups. Quercetin showed statistically highly significant ulcer size reduction as compared to benzydamine hydrochloride. Conclusion From the present study, it is evident that quercetin is safe, well tolerated, and effective therapy which promotes complete ulcer healing in a short duration of time.
Highlights
Background and ObjectivesRecurrent aphthous stomatitis is an inflammatory condition present since ancient era wherein numerous treatment modalities have been tried
Several biological and pharmacological functions have been ascribed to quercetin, including strong antioxidant and anti-inflammatory properties [5]
The present randomized, prospective, parallel-group, active controlled clinical study was conducted in the Department of Oral Medicine and Radiology, College of Dental Sciences, Davangere, from 2012 to 2014, wherein 40 patients with characteristic clinical features of minor aphthous ulcers and willing to undertake the treatment until complete healing of the ulcer were included
Summary
Background and ObjectivesRecurrent aphthous stomatitis is an inflammatory condition present since ancient era wherein numerous treatment modalities have been tried. Complete eradication of the disease has not been possible and newer agents are being introduced. One such agent is a flavonoid named quercetin with proven antioxidant, anti-inflammatory, and ulcer healing properties. Group A patients were advised to apply quercetin gel and Group B patients were advised to take benzydamine hydrochloride mouth wash. Each criterion was compared and statistically analyzed. There was statistically significant reduction in the mean score of pain sensation and ulcer area in both the groups. Quercetin showed statistically highly significant ulcer size reduction as compared to benzydamine hydrochloride. It is evident that quercetin is safe, well tolerated, and effective therapy which promotes complete ulcer healing in a short duration of time
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