Abstract
The intravenous injection of oxytocin or 8-lysine-vasopressin at a rate of 2 ×10-5 pinoles per kg per hr produced a significant decrease in the concentration of the FFA of the plasma of nondiabetic and alloxandiabetic dogs. A similar decrease was not produced in the nondiabetic dog with less than 3O×1O-5 pinoles insulin per kg per hr. The alloxan-diabetic dog, however, appeared to require a smaller dose of insulin to induce the same decrease in the plasma FFA. The reduction of the plasma FFA was independent of an increased removal of glucose from the blood. Doses of oxytocin and vasopressin that significantly reduced the FFA of the plasma produced a small increase in blood glucose, while the dose of insulin that was similarly effective produced no significant change in the blood glucose concentration.
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