Abstract
BackgroundThis study aimed to develop a novel indicator associated with hypertension in Chinese children and adolescents, the relative children’s lipid accumulation product (RCLAP).MethodsA cross-sectional study was conducted in 2018. A total of 683 students aged 8–15 years were recruited via a stratified cluster sampling Methods. Anthropometric indexes (waist circumference (WC), Body mass index (BMI), Waist-height ratio (WHtR), logarithm children LAP (LnCLAP), RCLAP per height (RCLAP-H)) were standardized using a z-score method (standardized variables: SWC, SBMI, SWHtR, SLnCLAP, SRCLAP-H). A logistic regression model was performed to evaluate the association of the above indicators with the outcome of hypertension.ResultsThe overall prevalence of hypertension was 5.7% (5.5% in boys, 6.0% in girls). SWC ≥ P75, SBMI ≥ P75, SWHtR ≥ P75, SlnCLAP ≥ P75 and SRCLAP-H ≥ P75 significantly increased risk of hypertension, with odds ratios (OR) of 2.21 (95% confidence interval (CI): 1.13, 4.30), 2.30 (1.18, 4.49), 2.64 (1.35, 5.14), 4.43 (2.28, 8.61), and 4.49 (2.31, 8.71), respectively.ConclusionRCLAP is a novel indicator associated with hypertension in Chinese children and adolescents, and it performs better than WC, BMI, WHtR and children LAP.
Highlights
Hypertension is the most common risk factor for cardiovascular disease (CVD) morbidity and mortality, and it has been found to be seriously harmful to human health worldwide [1, 2]
relative children’s lipid accumulation product (RCLAP) is a novel indicator associated with hypertension in Chinese children and adolescents, and it performs better than waist circumference (WC), body mass index (BMI), waist-toheight ratio (WHtR) and children lipid accumulation product (LAP)
The results of chi-square test showed that Standardized weight (Sweight), Standardized waist circumference (SWC), Standardized abdominal skinfold thickness (SAST), Standardized triglycerides (STG), Standardized body mass index (SBMI), Standardized Waist-height ratio (SWHtR), Standardized logarithmic children’s lipid accumulation product (SlnCLAP) and SRCLAP-H were significantly associated with hypertension in sample children (P < 0.05)
Summary
Hypertension is the most common risk factor for cardiovascular disease (CVD) morbidity and mortality, and it has been found to be seriously harmful to human health worldwide [1, 2]. Childhood hypertension was once considered a rare disease, but it is a major public health problem worldwide [3,4,5,6]. Childhood hypertension increases the prevalence of adulthood hypertension and increases the morbidity and mortality from cardiovascular disease [9,10,11,12,13]. This study aimed to develop a novel indicator associated with hypertension in Chinese children and adolescents, the relative children’s lipid accumulation product (RCLAP). A logistic regression model was performed to evaluate the association of the above indicators with the outcome of hypertension
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